The Foundational Molecule: Dr. Nathan Bryan on Why Nitric Oxide Changes Everything

In this groundbreaking episode of The Longevity Formula, Dr. Brandon Crawford sits down with renowned nitric oxide biochemist, Dr. Nathan S. Bryan, to discuss the revolutionary potential of a single molecule that regulates nearly every vital function in the body.

The conversation starts with Dr. Bryan's bold, widely publicized statement: "The cure for Alzheimer's already exists," a claim he fully backs with data linking nitric oxide deficiency to the core mechanism of the disease.

Dr. Bryan breaks down what nitric oxide is—a naturally produced signaling gas—and why its production is essential for longevity. It regulates blood flow, controls insulin sensitivity, mobilizes stem cells, prevents oxidative stress, and inhibits inflammation. Dr. Crawford and Dr. Bryan address why most physicians overlook this crucial molecule: because it's a gas with a half-life of less than a second, it's not easily measurable in a standard clinical setting.

Key Areas of Nitric Oxide Regulation

1. Mitochondrial Function: Nitric oxide is key to regulating the efficiency of oxygen utilization to produce cellular energy (ATP). It also induces mitochondrial biogenesis, generating more energy more efficiently.
2. The Light Environment: Dr. Bryan highlights the crucial role of light in our environment, particularly emphasizing that adequate sun exposure, specifically to UVA and infrared light, is essential for the release of stored nitric oxide from the skin and the overall regulation of this process.
3. The Oral Microbiome: Dr. Bryan argues that disease starts in the mouth, and the widespread use of antiseptic mouthwash and fluoride is destroying the oral microbiome, which is essential for the second major pathway of nitric oxide production. This dysregulation is a direct driver of hypertension.
4. Hypertension and Heart Health: Dr. Bryan explains the physics of hypertension (P=VR), showing that normalizing blood pressure relies on dilating blood vessels by producing nitric oxide, an approach often sidestepped by traditional medications. He details how restoring nitric oxide production can often normalize blood pressure and improve metrics like Heart Rate Variability (HRV).
5. Stem Cell Mobilization: Dr. Bryan references his research showing that nitric oxide is the signal that tells the body's own stem cells to mobilize and differentiate, a critical step for healing and regeneration.

The episode concludes with Dr. Bryan detailing his patented, orally disintegrating lozenge—a solid dose form of nitric oxide gas designed to bypass enzyme deficiency and restore the body’s natural production. He shares his incredible mission: to provide safe, effective nitric oxide therapies that allow patients to get off prescription medications, even as he faces significant pushback from the pharmaceutical industry.

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